https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54520 5% O2. Through the generation of a germline-specific Epas1 knockout mouse line, and through modulation of EPAS1 levels in primary cultures of spermatogonia with the small drug molecule Daprodustat, we have demonstrated that EPAS1 is required for robust SSC function in regenerative conditions (post-transplantation and post-chemotherapy), via the regulation of key cellular processes such as metabolism. These findings shed light on the relationship between hypoxia and male fertility and will potentially facilitate optimization of in vitro culture conditions for infertility treatment pipelines using SSCs, such as those directed at pediatric cancer survivors.]]> Wed 28 Feb 2024 16:12:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30796 60 years), whereas neutrophilic bronchitis (NB) was defined as high total cell count (=5.1×10 6 cells/mL) plus an increased age-corrected neutrophil proportion. The optimal cut-off for sputum colour to predict neutrophilic inflammation and NB was determined using receiver operator characteristic curve analysis. Results: A sputum colour score of =3 represented and predicted neutrophilic inflammation with modest accuracy (area under the curve (AUC)=0.64; p < 0.001, specificity=78.4%, sensitivity=49.2%). Participants with a sputum colour score of =3 had significantly (p < 0.05) higher CXCL-8, total cells and neutrophil number and proportion. Sputum colour score was also positively correlated with these factors. Sputum colour score =3 predicted NB with reasonably good accuracy (AUC=0.79, p < 0.001, specificity=79.3%, sensitivity=70.7%). Conclusions: Visual gradation of sputum colour in asthma relates to high total cell count and neutrophilic inflammation. Assessment of sputum colour can identify adults with asthma who are likely to have NB without the need for spu tum processing and differential cell count, which may facilitate asthma management.]]> Wed 09 Mar 2022 16:04:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49001 Wed 03 May 2023 12:10:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43341 Thu 15 Sep 2022 15:18:39 AEST ]]>